Rabbit monoclonal antibody [E63] to BaxThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide within Human Bax aa 1-100 (N terminal). The exact sequence is proprietary.
Conjugation
Agarose
Modification
Acetylated
Key Feature
Clonality
Monoclonal
Isotype
IgG
Clone Number
E63
Host Species
Rabbit
Tested Applications
ELISAIHC-PIPWB
WB:1:500~1:2000 IHC-P:1:50~1:200
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
BCL2L4 BAX
Target
Bax
Application
Application
IHC-P ImageIHC-P analysis of human lymph node using Bax antibody [E63] at a dilution of 1:200.
Application
WB ImageWB analysis of HeLa cell lysate using Bax antibody [E63] at a dilution of 1:2,000.
Application Notes
WB:1:500~1:2000 IHC-P:1:50~1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
PBS containing 50% Glycerol, 0.05% BSA and 0.01% Sodium azide.