Rabbit Polyclonal antibody to BCL2L10The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
Immunogen
Bcl-B antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human Bcl-B.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAICC/IFWB
WB: 1 ug/ml. ICC: 10 ug/ml:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Immunocytochemistry of Bcl-B in Jurkat cells with Bcl-B antibody at 10 ug/mL.
Application
Western blot analysis of Bcl-B in Jurkat lysate with Bcl-B antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Application Notes
WB: 1 ug/ml. ICC: 10 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
Be stored at 4oC for three months and -20oC, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.