Rabbit Polyclonal antibody to BCL6The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Immunogen
BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAWB
WB: 1 ug/ml:
Species Reactivity
Rat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Three alternatively spliced transcript variants have been observed
Application
Application
Western blot analysis of BCL6 in rat lung tissue lysate with Bcl6 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide
Application Notes
WB: 1 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
Be stored at 4oC for three months and -20oC, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.