Application
Western blot analysis of Beta-catenin (pT41/S45) expression in HeLa (A); HepG2 (B) whole cell lysates.| Product Name | beta Catenin (phospho Thr41/Ser45) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to beta Catenin (phospho Thr41/Ser45)The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta-catenin. The exact sequence is proprietary. |
| Modification | p-Thr41/Ser45 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MRD19 armadillo catenin (cadherin-associated protein) beta 1 88kDa CTNNB CTNNB1 |
|---|---|
| Target | beta Catenin |
| Tissue Specificity | Recognizes endogenous levels of Beta-catenin (pT41/S45) protein. |
Application
Western blot analysis of Beta-catenin (pT41/S45) expression in HeLa (A); HepG2 (B) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
