Application
Western blot analysis of extracts from LOVO cells, using Ik3-1 Antibody. The lane on the right is treated with the synthesized peptide.| Product Name | CABLES1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CABLES1Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CABLES1. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| ELISA: 1:20000Optimal dilutions should be determined experimentally by the end user.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Cdk5 and Abl enzyme substrate1 FLJ35924 Ik31 Cdk5 and Abl enzyme substrate 1 |
|---|---|
| Target | CABLES1 |
| Molecular Weight(MW) | 67 kDa (note) |
| Tissue Specificity | Ik3-1 Antibody detects endogenous levels of total Ik3-1 protein. |
| Cellular Localization | Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons. |
Application
Western blot analysis of extracts from LOVO cells, using Ik3-1 Antibody. The lane on the right is treated with the synthesized peptide.| Application Notes | ELISA: 1:20000Optimal dilutions should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 degrees Celcius. Product is stable for at least 1 year. |
| Storage Buffer | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
