Rabbit polyclonal antibody to Caspase 7This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Immunogen
A 16 amino acid peptide from human Caspase 7 amino-terminus.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
Western Blotting: Max Dilution 0.5 ug/ml:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CASP-7 ICE-LAP3 CMH-1 CASP7 LICE2 MCH3
Target
Caspase-7
Tissue Specificity
This antibody recognizes the N-Terminal region of Caspase 7.
Application
Application
IHC-P analysis of rat skeletal muscle tissue using Caspase 7 antibody, N-term.
Application
WB analysis of mouse skeletal muscle tissue lysate using Caspase 7 antibody at (A)0.5 and (B)1 ug/ml
Application Notes
Western Blotting: Max Dilution 0.5 ug/ml:
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.