Application
Western blot analysis of Caveolin 1 (pY14) expression in A549 (A); HeLa pervanadate-treated (B) whole cell lysates.| Product Name | Caveolin 1 (phospho Tyr14) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Caveolin 1 (phospho Tyr14)The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Caveolin 1 (pY14). The exact sequence is proprietary. |
| Modification | p-Tyr14 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CAV1 MSTP085 caveolin 1 caveolae protein 22kDa VIP21 BSCL3 LCCNS PPH3 CGL3 |
|---|---|
| Target | Caveolin 1 (phospho Tyr14) |
| Tissue Specificity | Recognizes endogenous levels of Caveolin 1 (pY14) protein. |
Application
Western blot analysis of Caveolin 1 (pY14) expression in A549 (A); HeLa pervanadate-treated (B) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide. |
