Rabbit Polyclonal antibody to CBX2 (chromobox homolog 2 (Pc class homolog, Drosophila))This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Immunogen
Recombinant protein encompassing a sequence within the center region of human CBX2. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
HumanMouse
Predicted Reactivity
Rat, Zebrafish, Xenopus laevisRat (98%), Zebrafish (80%), Xenopus laevis (89%)
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CDCA6 antibody M33 antibody MGC10561 antibody CBX2 antibody modifier 3 antibody "chromobox homolog 2 (Pc class homolog Drosophila) antibody" Pc class homolog antibody chromobox protein homolog 2 antibody cell division cycle associated 6 antibody
Molecular Weight(MW)
56 kDa (note) (2)
Cellular Localization
Nucleus
Application
Application
Sample (30 ug of whole cell lysate) A: A431 12% SDS PAGE diluted at 1:1000
Application
Immunohistochemical analysis of paraffin-embedded C2C12 xenograft, using CBX2 antibody at 1:500 dilution.
Positive Control
A431 , Jurkat
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.