| Product Name | CCKAR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to CCKARThe cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction. |
| Immunogen | Poly Lysin conjugated synthetic peptide: RFLLPPNDVMQQSWH, corresponding to amino acids 197-210 of Human CCKAR. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a dilution of 1/2000. Detects a band of approximately 48 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanPigGuinea Pig |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CCK1-R CCKRA CCKA 118444 P32238 CCKAR CCK1R 886 CCK-A CCK A CCK1 R |
|---|---|
| Target | CCKAR |
| Cellular Localization | Integral membrane protein |
| Application Notes | WB: Use at a dilution of 1/2000. Detects a band of approximately 48 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
