| Product Name | CCR5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to CCR5Human immunodeficiency virus (HIV) and related virus require co-receptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors includingCCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV co-receptors (1,2). Among them, CCR5 (CC-CKR-5) is a principal co-receptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells (3,4). CCR5 is required for the infection by HIV-1, HIV-2, and SIV (1,2). The b-chemokines RANTES, MIP-1a and MIP-1b are the ligands for CCR5 and prevent infection by M-tropic HIV-1(3-5). CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells (6,7). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites (8,9). CCR5 messenger RNA is expressed in lymphoid organs and monocytes. |
| Immunogen | Synthetic peptide, corresponding to amino acids 6-20 of Human CCR 5. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blot (1:1000 to 1:2000)Not yet tested in other applications.: |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Gene Synonyms | CCR5 CCCKR5 CMKBR5 601373 CD195 CKR5 P51681 CC-CKR-5 CKR-5 1234 CKR 5 CC CKR 5 |
|---|---|
| Target | CCR5 |
| Tissue Specificity | This antibody recognises the N-terminal region of the chemokine receptor CCR5. |
| Cellular Localization | Integral membrane protein |
| Positive Control | THP-1 whole cell lysate |
|---|---|
| Application Notes | Western blot (1:1000 to 1:2000)Not yet tested in other applications.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide |
