Rabbit polyclonal to CXCR4CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library (ref 1). Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor forHIV-2's binding to CD4 through envelope glycoprotein gp 120 (ref 2). In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells (ref 3). Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Immunogen
Recombinant full length protein (Rat).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
FACSIMWB
WB: Use at a dilution of 1/2000. Optimal dilutions/concentrations should be determined by the end user.:
Species Reactivity
MouseRat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)