| Product Name | Cyclin E antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal to Cyclin ECyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers. |
| Immunogen | A synthetic peptide derived from the C-terminus of human Cyclin E |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IPWB |
| For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | CCNE1 CCNE P24864 898 123837 Cyclin E |
|---|---|
| Target | Cyclin E |
| Cellular Localization | Nuclear |
| Positive Control | SKBR3 and MAD109 Cells |
|---|---|
| Application Notes | For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | 10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide |
