Application
Western blots analysis of Cyr61 expression with lysate from Jurkat cells (Lane 1) and mouse small intenstine tissue (Lane 2).| Product Name | CYR61 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to CYR61CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor inducible immediate-early gene. It promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion and appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA A, VEGA C, MMP1, MMP3, TIMP1, uPA, PAI 1 and integrins alpha 3 and alpha 5. Cyr61 mediated gene regulation is dependent on heparin binding. Down-regulates the expression of alpha-1 and alpha 2 subunits of collagen type 1. Promotes cell adhesion and adhesive signaling through integrin alpha 6/beta 1, cell migration through integrin alpha v/beta 5 and cell proliferation through integrin alpha v/beta 3. |
| Immunogen | Synthetic peptide from CYR61 (Human) |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a concentration of 1 - 4 μg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 42 kDa). Not yet tested in other applications.Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | IGFBP10 O00622 3491 CCN1 602369 CYR61 GIG1 |
|---|---|
| Target | CYR61 |
Application
Western blots analysis of Cyr61 expression with lysate from Jurkat cells (Lane 1) and mouse small intenstine tissue (Lane 2).| Application Notes | WB: Use at a concentration of 1 - 4 μg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 42 kDa). Not yet tested in other applications.Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For long term storage, please keep at -70°C or below. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: 50% Glycerol, 1% BSA, PBS. pH 7.2 |
