Rabbit Polyclonal antibody to Cystatin CThe cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth mu
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminal of human Cystatin C.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHC-PWB
ICC/IF:1:100~1:200 IHC-P:1:20~1:100 WB:1:250~1:1000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
Human
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
cystatin C ARMD11 CST3
Target
Cystatin C
Application
Application
ICC of MCF-7 cells
Application
IHC-P of human mammary cancer tissue
Application
Lane 1: Recombinant Human Cystatin C Protein 10ng Lane 2: Recombinant Human Cystatin C Protein 5ng Lane 3: Recombinant Human Cystatin C Protein 2.5ng
Application Notes
ICC/IF:1:100~1:200 IHC-P:1:20~1:100 WB:1:250~1:1000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC. Avoid multiple freeze-thaw cycles.