Rabbit Polyclonal antibody to Cytochrome P450 2C9This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 2C9. The exact sequence is proprietary.
Modification
Acetylated
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB:1:500~1:2000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CPC9 CYPIIC9 cytochrome P450 family 2 subfamily C member 9 CYP2C9 P450IIC9 CYP2C CYP2C10
Target
Cytochrome P450 2C9
Tissue Specificity
Recognizes endogenous levels of Cytochrome P450 2C9 protein.
Application
Application
Western blot analysis of Cytochrome P450 2C9 expression in HeLa (A); Raw264.7 (B); PC12 (C) whole cell lysates.
Application Notes
WB:1:500~1:2000
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles.
Storage Buffer
Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.