Application
IHC analysis of human small inestine tissue using DC-SIGN antibody.Application
WB analysis of human placenta tissue lysate using DC-SIGN antibody in the absence (lane 1) and presence (lane 2) of blocking peptide| Product Name | DC-SIGN antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to DC-SIGNThis gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i |
| Immunogen | Synthetic peptide corresponding to amino acids 277-293 of human DC-SIGN. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC-FIHC-PWB |
| Western Blotting: 1 ug/ml - 2 ug/ml Optimal dilution / concentration should be determined by the end user.: |
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| Species Reactivity | HumanSheep |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CD209 molecule CD209 DC-SIGN1 CLEC4L CDSIGN |
|---|---|
| Target | DC-SIGN |
| Tissue Specificity | This antibody detects a band of approximately 44 kD by western blot. |
Application
IHC analysis of human small inestine tissue using DC-SIGN antibody.
Application
WB analysis of human placenta tissue lysate using DC-SIGN antibody in the absence (lane 1) and presence (lane 2) of blocking peptide| Application Notes | Western Blotting: 1 ug/ml - 2 ug/ml Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | Phosphate buffered saline containing 0.02% Sodium Azide |
