Rabbit polyclonal to ESE1Epithelium-specific gene regulation plays a critical role during embryogenesis, and the epithelial cell lineage is the first differentiated cell type to appear after fertilization. Until recently, very few epithelial cell-restricted transcription factors had been described. Members of the ets transcription factor/oncogene family have been implicated in human carcinogenesis following the discovery of several distinct chromosomal translocations involving members of the ets family in different types of cancer. ets factors play key roles in transcriptional control of stringently regulated genes, such as genes involved in tissue development, differentiation, angiogenesis, cell cycle control and cell proliferation. ESE-1 is the first member of the ets family that was found to be exclusively expressed and inducible in epithelial cells.
Immunogen
N-terminal sequence MAATCEISNIFSNYFS and C-terminal sequence SSGWKEEEVLQSRN of human ESE-1 protein.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAWB
Immunoblotting: use at 1:500-1:1,000 dilution. ELISA: use at 1:1,000-1:5,000 dilution:
Species Reactivity
Human
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)