Application
Western blot analysis of Estrogen Receptor alpha (pY537) expression in HeLa (A); SP2/0 (B); rat spleen (C) whole cell lysates.| Product Name | Estrogen Receptor alpha (phospho Tyr537) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Estrogen Receptor alpha (phospho Tyr537)This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Estrogen Receptor alpha. The exact sequence is proprietary. |
| Modification | p-Tyr537 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Era ESRA estrogen receptor 1 ESR ESR1 NR3A1 ESTRR ER |
|---|---|
| Target | Estrogen Receptor alpha (phospho Tyr537) |
| Tissue Specificity | Recognizes endogenous levels of Estrogen Receptor alpha (pY537) protein. |
Application
Western blot analysis of Estrogen Receptor alpha (pY537) expression in HeLa (A); SP2/0 (B); rat spleen (C) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 °C. Upon delivery aliquot and store at -20 °C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide. |
