Application
WB analysis of extracts from various cell lines using Factor XII antibody.Application
IHC-P analysis of rat kidney tissue using Factor XII antibody at a dilution of 1:100.| Product Name | Factor XII antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Factor XIIThis gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical sympto |
| Immunogen | Recombinant protein of human F12 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| WB: 1:500 - 1:2000. IHC: 1:50 - 1:200: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | HAEX coagulation factor XII (Hageman factor) F12 HAE3 HAF |
|---|---|
| Target | Factor XII |
| Molecular Weight(MW) | 68 kDa (note) |
Application
WB analysis of extracts from various cell lines using Factor XII antibody.
Application
IHC-P analysis of rat kidney tissue using Factor XII antibody at a dilution of 1:100.| Application Notes | WB: 1:500 - 1:2000. IHC: 1:50 - 1:200: |
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| Form | Liquid |
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| Storage Instructions | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
