| Product Name | FOXO4 (phospho Ser193) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to FOXO4 ( phospho S193 )The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX, AND FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253. |
| Immunogen | Available on request. |
| Modification | p-Ser193 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a concentration of 1 - 2 μg/ml. In Western blot, this antibody detects a band of approximately 62 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
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| Species Reactivity | HumanMouse |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AFX1 4303 300033 AFX FOXO4 MGC120490 MLLT7 P98177 FOXO4 (phospho S193) FOXO4 (phospho Ser193) FOXO4 (pS193) FOXO4 (pSer193) FOXO4 phospho S193 FOXO4 phospho Ser193 Phospho FOXO4 (S193) Phospho FOXO4 (Ser193) Phospho FOXO4 (pS193) Phospho F |
|---|---|
| Target | FOXO4 |
| Tissue Specificity | This antibody recognizes the phosphorylated Ser193 of AFX. It does not react with non-phosphorylated AFX. |
| Application Notes | WB: Use at a concentration of 1 - 2 μg/ml. In Western blot, this antibody detects a band of approximately 62 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS pH7.2 with 50% glycerol, 1% BSA and 0.02% sodium azide |
