Application
Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 ug/mL.Application
Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 ug/ml.Application
Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.| Product Name | Grik4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Grik4Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Glutamate receptor KA1 Excitatory amino acid receptor1 Glutamate receptor ionotropic kainate4 precursor EEA1 Glutamate receptor KA-1 Excitatory amino acid receptor 1 Grik4 Glutamate receptor ionotropic kainate 4 precursor Glutamate receptor KA 1 |
|---|---|
| Target | Grik4 |
| Tissue Specificity | This antibody is specific for Grik4 |
Application
Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 ug/mL.
Application
Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 ug/ml.
Application
Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.| Positive Control | Blocking Peptide: Cat.No. GTX85044-PEP - Grik4 Peptide Lysates: Cat. No. GTX27942 - Rat Brain Tissue Lysate |
|---|---|
| Application Notes | ICC/IF:1:200~1:500 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Antibody is supplied in PBS containing 0.02% sodium azide |
