Rabbit Polyclonal antibody to h2afzVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-W
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Zebra Fish
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
H2A histone family member V antibody "H2A histone family member Z antibody" h2afv antibody h2afz antibody
Molecular Weight(MW)
14 kDa (note)
Cellular Localization
Nucleus
Application
Application
Immunohistochemical analysis (whole mount) of zebrafish embryo, using h2afz antibody at 1:200 dilution.
Positive Control
zebrafish embryo
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.