Rabbit Polyclonal antibody to Integrin beta 4 (phospho Tyr1494)Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen
KLH conjugated Synthesised phosphopeptide derived from human ITGB4 around the phosphorylation site of Tyr1494
Modification
p-Tyr1494
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-P
IHC-P(1:100-500):
Species Reactivity
Rat
Predicted Reactivity
Bovine, Rabbit, Horse, Pig, Dog
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)