| Product Name | JNK1 (phospho Thr183/Tyr185) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to JNK1 (phospho T183 + Y185)MAP kinases consist of several subgroups, including the ERK, JNK, and p38 kinases. The members are regulated by many different extracellular cues ranging from cytokines, growth factors, and neuropeptides. These stimuli activate cell surface receptors to stresses such as cold, heat, osmolarity changes and irradiation. The pathways regulated by the MAPKs control a broad array of cellular responses ranging from survival, cell proliferation, and apoptosis. The MAPKs family is also characterized by their requirement for dual phosphorylation at a conserved threonine and tyrosine residue for enzymatic activation and both must be phosphorylated for full enzymatic activation. The closely related ERK1 (44 kDa) and ERK2 (42 kDa) kinases are characterized by their requirement for dual phosphorylation at a conserved T-E-Y motif. While JNK1 is activated by dual phosphorylation at a T-P-Y motif and p38 is also activated by dual phosphorylation at a T-G-Y motif. |
| Immunogen | Synthetic peptide mapping to an internal domain containing phosphorylated T183/Y185. |
| Modification | p-Thr183/Tyr185 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | JAK1A JNK1 Tyrosine protein kinase JAK1 JNK1 (phospho T183/Y185) JNK1 (phospho Thr183/Tyr185) JNK1 (pT183/pY185) JNK1 (pThr183/pTyr185) JNK1 phospho T183/Y185 JNK1 phospho Thr183/Tyr185 Phospho JNK1 (T183/Y185) Phospho JNK1 (Thr183/Tyr185) Phosp |
|---|---|
| Target | JNK1 |
| Application Notes | For WB: Use at a dilution of 1:200. Optimal dilutions/concentrations should be determined by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin |
