Application
KIDINS220 antibody [C3], C-term detects KIDINS220 protein at membrane on mouse esophagus by immunohistochemical analysis. Sample: Paraffin-embedded mouse esophagus. KIDINS220 antibody [C3], C-term dilution: 1:500.Application
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using KIDINS220 antibody at 1:500 dilution.Application
Sample(30 ug whole cell lysate) A:H1299 B:Raji 5% SDS PAGE diluted at 1:1000| Product Name | KIDINS220 antibody [C3], C-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to KIDINS220Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human KIDINS220. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | HumanMouse |
| Predicted Reactivity | RatRat (100%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | ARMS antibody, MGC163482 antibody, KIDINS220 antibody, kinase D-interacting substrate of 220 kDa antibody, ankyrin repeat-rich membrane spanning antibody, ankyrin repeat-rich membrane-spanning protein antibody, "kinase D-interacting substrate, 220kDa antib |
|---|---|
| Target | KIDINS220 |
| Molecular Weight(MW) | 197 kDa (note) |
| Cellular Localization | Membrane; Multi-pass membrane protein |
Application
KIDINS220 antibody [C3], C-term detects KIDINS220 protein at membrane on mouse esophagus by immunohistochemical analysis. Sample: Paraffin-embedded mouse esophagus. KIDINS220 antibody [C3], C-term dilution: 1:500.
Application
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using KIDINS220 antibody at 1:500 dilution.
Application
Sample(30 ug whole cell lysate) A:H1299 B:Raji 5% SDS PAGE diluted at 1:1000| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
