Rabbit Polyclonal antibody to LBP (lipopolysaccharide binding protein)The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the center region of human LBP. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
MGC22233 antibody LBP antibody lipopolysaccharide-binding protein antibody LPS-binding protein antibody "BPI fold containing family D member 2 antibody" lipopolysaccharide binding protein antibody
Molecular Weight(MW)
53 kDa (note)
Cellular Localization
Secreted
Application
Application
Immunohistochemical analysis of paraffin-embedded human gastric N+T, using LBP antibody at 1:100 dilution.
Application
Sample(30 ug whole cell lysate) A:H1299 7.5% SDS PAGE diluted at 1:500
Positive Control
A431 , H1299
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.