Application
Sample (30 ug of whole cell lysate) A: IMR32 5% SDS PAGE diluted at 1:1000| Product Name | MAGI3 antibody , N-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human MAGI3. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Chicken, BovineMouse (96%), Rat (95%), Chicken (93%), Bovine (96%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MAGI-3 antibody, MGC163281 antibody, RP4-730K3.1 antibody, dJ730K3.2 antibody, MAGI3 antibody, membrane-associated guanylate kinase inverted 3 antibody, "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 antibody", membrane-assoc |
|---|---|
| Molecular Weight(MW) | 166 kDa (note) (3) |
Application
Sample (30 ug of whole cell lysate) A: IMR32 5% SDS PAGE diluted at 1:1000| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
