| Product Name | MBTPS1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MBTPS1 (membrane-bound transcription factor peptidase, site 1)The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MBTPS1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Zebrafish, Xenopus laevis, BovineMouse (96%), Rat (96%), Zebrafish (85%), Xenopus laevis (86%), Bovine (93%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | KIAA0091 antibody MGC138711 antibody MGC138712 antibody PCSK8 antibody S1P antibody SKI-1 antibody MBTPS1 antibody subtilisin/kexin-isozyme 1 antibody membrane-bound transcription factor site-1 protease antibody endopeptidase S1P antibody "membra |
|---|---|
| Molecular Weight(MW) | 118 kDa (note) |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein , Golgi apparatus membrane; Single-pass type I membrane protein |
| Positive Control | Target recombinant protein |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
