Application
Western blot analysis of extracts of mouse intestine tissue lysate, using MC1R antibody.Application
Immunohistochemistry of paraffin-embedded human kidney cancer tissue using MC1R antibody at dilution of 1:200 (x400 lens)| Product Name | MC1 Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to MC1 ReceptorThis intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant protein of human MC1R |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIHC-PWB |
| WB 1:500 - 1:2000, IHC 1:50 - 1:200: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) MC1R CMM5 MSH-R SHEP2 |
|---|---|
| Target | MC1 Receptor |
| Molecular Weight(MW) | 35 kDa (note) |
Application
Western blot analysis of extracts of mouse intestine tissue lysate, using MC1R antibody.
Application
Immunohistochemistry of paraffin-embedded human kidney cancer tissue using MC1R antibody at dilution of 1:200 (x400 lens)| Application Notes | WB 1:500 - 1:2000, IHC 1:50 - 1:200: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
