Application
Sample(30 μg of whole cell lysate) A:293T B:A431 7.5% SDS PAGE diluted at 1:500| Product Name | mGluR3 antibody , C-term |
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| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to mGluR-3 (glutamate receptor, metabotropic 3)L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq] |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human mGluR-3. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, BovineMouse (100%), Rat (100%), Bovine (100%) |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | GLUR3 antibody GPRC1C antibody MGLUR3 antibody mGlu3 antibody GRM3 antibody glutamate metabotropic receptor 3 antibody metabotropic glutamate receptor 3 antibody "glutamate receptor metabotropic 3 antibody" |
|---|---|
| Target | mGluR-3 |
| Molecular Weight(MW) | 99 kDa (note) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
Application
Sample(30 μg of whole cell lysate) A:293T B:A431 7.5% SDS PAGE diluted at 1:500| Positive Control | 293T , A431 , H1299 , HeLaS3 |
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| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
