Rabbit polyclonal antibody to MKL1Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.
Immunogen
The antiserum was produced against synthesized peptide derived from human MKL1.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAWB
ELISA: 1:1000Optimal dilutions should be determined experimentally by the end user.:
Species Reactivity
HumanMouse
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
Myocardinrelated transcription factor A Megakaryocytic acute leukemia protein MKL1 Myocardin-related transcription factor A Megakaryoblastic leukemia1 protein MRTF-A Megakaryoblastic leukemia 1 protein MRTFA MRTF A
Target
MKL1
Molecular Weight(MW)
98 kDa (note)
Tissue Specificity
MKL1 Antibody detects endogenous levels of total MKL1 protein.
Application
Application
Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide.
Application Notes
ELISA: 1:1000Optimal dilutions should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20 degrees Celcius. Product is stable for at least 1 year.
Storage Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.