| Product Name | MSH2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to MSH2MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma (HNPCC) (Lynch syndrome) cases. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. |
| Immunogen | Full length recombinant MSH2 protein. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-FIHC-PIPWB |
| For IHC-Fr: Use at a concentration of 2 μg/ml. For IHC-P and IP: Use at an assay dependent dilution. For WB: Use at a concentration of 1 - 1.5 μg/ml. Predicted molecular weight: 100 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Gene Synonyms | HNPCC P43246 114030 FCC1 MSH2 4436 COCA1 HNPCC1 LCFS2 |
|---|---|
| Target | MSH2 |
| Cellular Localization | Nuclear |
| Positive Control | HCT116 OR SW480 cells |
|---|---|
| Application Notes | For IHC-Fr: Use at a concentration of 2 μg/ml. For IHC-P and IP: Use at an assay dependent dilution. For WB: Use at a concentration of 1 - 1.5 μg/ml. Predicted molecular weight: 100 kDa. Optimal dilutions/concentrations should be determined by the researcher.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | 50% Glycerol, 50mM Sodium phosphate, no preservatives added |
