Rabbit Polyclonal antibody to NAC1Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Immunogen
Peptide sequence around aa.519~523(A-G-P-S-A) derived from Human NAC1
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
BEND8 BTBD14B FLJ37383 NAC-1 NAC1 NACC1 BTB (POZ) domain containing 14B nucleus accumbens-associated protein 1 transcriptional repressor NAC1 BEN domain containing 8 BTB/POZ domain-containing protein 14B nucleus accumbens associated 1 BEN and B
Target
NAC1
Molecular Weight(MW)
62 (note)
Application
Application
Western blot analysis of extracts from Rat and Mouse brain tissue using NAC1 Antibody
Application Notes
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.