Application
B. Immunohistochemical staining of paraffin-embedded human brain gilioma using anti-NFGR RabMAb (cat. # ).Application
A. Western blot analysis on PC12 cell lysate using anti-NFGR RabMAb (cat. # ).| Product Name | NGF Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit monoclonal antibody [EP1039Y] to NGF ReceptorNeurotrophins signal cell survival, differentiation, growth cessation, and apoptosis through two classes of cell surface receptors, the Trks and NGF Receptor (p75NTR). p75NTR, when activated in the absence of a strong Trk signal, induces apoptosis of neurons, while in the presence of Trk it enhances responses to neurotrophin . p75NTR, when it is not bound by NGF, may play a role in neuronal selection during embryonic development and suggest that neuroblastomas may arise from immature neuroblasts that escape programmed cell death. Therefore, the loss of p75NTR expression in developing neural crest cells might be a primary event in the genesis of neuroblastoma . It has also been suggested that neuronal death in Alzheimer's disease is mediated, at least in part, by the interaction of beta-amyloid with p75NTR, and suggest new targets for therapeutic intervention . |
| Immunogen | A synthetic peptide corresponding to residues of human NGFR was used as an immunogen. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Clone Number | EP1039Y |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHC-PIPWB |
| For WB: Use at a dilution of 1:1,000-10,000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Gene Synonyms | p75NTR NGFR Gp80LNGFR p75(NTR) TNFRSF16 Gp80-LNGFR CD271 Gp80 LNGFR |
|---|---|
| Target | NGF Receptor |
| Molecular Weight(MW) | 75 (note) |
Application
B. Immunohistochemical staining of paraffin-embedded human brain gilioma using anti-NFGR RabMAb (cat. # ).
Application
A. Western blot analysis on PC12 cell lysate using anti-NFGR RabMAb (cat. # ).| Application Notes | For WB: Use at a dilution of 1:1,000-10,000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 °C. Stable for 12 months from date of receipt. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
