| Product Name | PARP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to PARPPARP is a 116 kDa nuclear protein which is strongly activated by DNA strand breaks. PARP plays a role in DNA repair as well as in other cellular processes, including DNA replication, cell proliferation and differentiation. During apoptosis, ICE family members, such as caspase 3 and 7, cleave PARP to yield an 89 kDa and a 24 kDa fragment. PARP cleavage is considered to be one of the classical characteristics of apoptosis. |
| Immunogen | Synthetic peptide mapping to the amino terminal domain of human PARP. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PIPWB |
| IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a dilution of 1/400. Reactive with the 112 KD and 29 KD fragments. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | pADPRT1 PARP-1 PARP pADPRT-1 ADPRT1 PARP1 173870 PPOL ADPRT ADPRT 1 PARP 1 pADPRT 1 |
|---|---|
| Target | PARP |
| Tissue Specificity | Reactive with the full length PARP and 24 KDa fragment of PARP |
| Cellular Localization | Nuclear |
| Application Notes | IHC-P: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a dilution of 1/400. Reactive with the 112 KD and 29 KD fragments. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: 0.2% Gelatin, PBS |
