Rabbit Polyclonal antibody to Polycystin 2 (polycystin-2)This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease. [provided by RefSeq]
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Polycystin 2. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Predicted Reactivity
Mouse, Rat, Pig, Chicken, BovineMouse (92%), Rat (87%), Pig (98%), Chicken (84%), Bovine (97%)
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
APKD2 antibody MGC138466 antibody MGC138468 antibody PC2 antibody PKD4 antibody Pc-2 antibody TRPP2 antibody PKD2 antibody autosomal dominant polycystic kidney disease type II protein antibody polycystwin antibody polycystin-2 antibody "transien
Molecular Weight(MW)
110 kDa (note) (2)
Cellular Localization
Membrane; Multi-pass membrane protein
Application
Application
Immunohistochemical analysis of paraffin-embedded HeLa xenograft, using Polycystin 2 antibody at 1:500 dilution.
Application
Sample (30 ug of whole cell lysate) A: U87-MG 7.5% SDS PAGE diluted at 1:500
Positive Control
U87-MG
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.