Application
Western blot analysis of extracts from COS7 cells treated with Adriamycin using Abl (Phospho-Tyr204) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | Abl (phospho Tyr204) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | p150, c-ABL, EC 2.7.10.2 |
| Product description | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).1) Meyn MA, et al. (2006) J Biol Chem 281, 30907-16 |
| Immunogen | Abl (phospho Tyr204) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y (p)-V-S) derived from Human c-Abl. |
| Modification | p-Tyr204 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ABL1 |
|---|---|
| Alternative Names | p150 c-ABL EC 2.7.10.2 |
| Molecular Weight(MW) | 135 kDa |
| Tissue Specificity | The antibody detects endogenous level of Abl only when phosphorylated at tyrosine 204. |
| Entrez Gene | 25 |
|---|---|
| Protein Accession | NP_005148.2 |
Application
Western blot analysis of extracts from COS7 cells treated with Adriamycin using Abl (Phospho-Tyr204) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
