The protein encoded by this gene is an isozyme of the
long-chain fatty-acid-coenzyme A ligase family. Although differing
in substrate specificity, subcellular localization, and tissue
distribution, all isozymes of this family convert free long-chain
fatty acids into fatty acyl-CoA esters, and thereby play a key role
in lipid biosynthesis and fatty acid degradation. This isozyme is
highly expressed in brain, and preferentially utilizes myristate,
arachidonate, and eicosapentaenoate as substrates. The amino acid
sequence of this isozyme is 92% identical to that of rat homolog.
Two transcript variants encoding the same protein have been found
for this gene.1) Weedon-Fekjaer, M.S., et al. J. Lipid Res. 51(7):1886-1896(2010)
Immunogen
This ACSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 528-556 amino acids from the C-terminal region of human ACSL3.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.