Application
Western blot analysis of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | ACVR1B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACVR1B Antibody: FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, Activin receptor type-1, Activin receptor type I, ACTR-I |
| Product description | ACVR1B Antibody: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.1) Tsuchida K, Sawchenko PE, Nishikawa S, et al. Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain. Mol. Cell. Neurosci.1996; 7:467-78. |
| Immunogen | ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B. The immunogen is located within amino acids 140 - 190 of ACVR1B. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| ACVR1B antibody can be used for detection of ACVR1B by Western blot at 1 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ACVR1B |
|---|---|
| Alternative Names | ACVR1B Antibody: FOP ALK2 SKR1 TSRI ACTRI ACVR1A ACVRLK2 Activin receptor type-1 Activin receptor type I ACTR-I |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Rat: (100%) |
| Tissue Specificity | At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C. |
Application
Western blot analysis of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1305 - Human Kidney Tissue Lysate |
|---|---|
| Application Notes | ACVR1B antibody can be used for detection of ACVR1B by Western blot at 1 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | ACVR1B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | ACVR1B Antibody is supplied in PBS containing 0.02% sodium azide. |
Data sheet for OM269844