| Product Name | Prion protein PrP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to Prion protein PrPPrion diseases or transmissible spongiform encephalopathies are neuro-degenerative diseases that affect both humans and animals (Prusiner 1998). All prion diseases share the same molecular pathogenic mechanism that involves conversion of normal cellular prion protein (PrPc) into a form that is insoluble in non ionic detergent and partially resistant to proteases (PrPsc) (Pan et al. 1993). Both PrPsc and PrPc are encoded within a single exon of a chromosomal gene as a protein of ~ 250 amino acids (Basler et al. 1986). Many mammalian PrPs have a 22 amino acid N-terminal signal sequence (Hope et al. 1986; Turk et al. 1988) and 23 amino acid C-terminal signal sequence encoding for attachment of a inositol-inositol anchor (Stahl et al. 1987, 1990). The mature protein of 209 amino acids contains one disulfide bond (Turk et al. 1988) and has two sites of asparagine-linked glycosylation (Endo et al. 1989; Oesch et al. 1995). |
| Immunogen | Recombinant fragment (Cow). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| The antibody is used for Western blot and ELISA (dilution 1:2000).Recognises recombinant protein ,GTX20753, in western blot and ELISA.: |
|
| Species Reactivity | HumanMouseBovine |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Prion protein PrP PRNP PrP2730 PrP33-35C 5621 ASCR PrP3335C GSS PrP27-30 CJD PRIP PrPc PrP MGC26679 P04156 123400 |
|---|---|
| Target | Prion protein PrP |
| Tissue Specificity | Recognises natural PrPc and conformationally changed PrPc (PrPsc). |
| Cellular Localization | Cell Membrane |
| Application Notes | The antibody is used for Western blot and ELISA (dilution 1:2000).Recognises recombinant protein ,GTX20753, in western blot and ELISA.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: Serum |
