This gene encodes a
GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which
is localized to the cytosolic side of the endoplasmic reticulum
(ER) and catalyzes the transfer of the fourth and fifth mannose
residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and
Man4GlcNAc2-PP-dolichol resulting in the production of
Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with
congenital disorder of glycosylation type Ip (CDGIP). This gene
overlaps but is distinct from the UTP14, U3 small nucleolar
ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the
GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has
been identified on chromosome 19.1) Rind, N., et al. Hum. Mol. Genet. 19(8):1413-1424(2010)
Immunogen
This ALG11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-468 amino acids from the C-terminal region of human ALG11.
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.