Application
Immunofluorescence of APBA2 in human brain tissue with APBA2 antibody at 20 μg/mL.Application
Western blot analysis of APBA2 in human brain tissue lysate with APBA2 antibody at (A) 1 and (B) 2 μg/mL.Application
Immunohistochemistry of APBA2 in human brain tissue with APBA2 antibody at 10 μg/mL.| Product Name | APBA2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APBA2 Antibody: X11L, MINT2, LIN-10, HsT16821, X11-BETA, D15S1518E, MGC:14091, X11L, Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Mint-2 |
| Product description | APBA2 Antibody: APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.1) Blanco G, Irving NG, Brown SDM, et al. Mapping of the human and murine X11-like genes (APBA2 and Apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer’s disease amyloid precursor protein. Mamm. Gen.1988; 9:473-5. |
| Immunogen | APBA2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APBA2. The immunogen is located within amino acids 290 - 340 of APBA2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| APBA2 antibody can be used for detection of APBA2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APBA2 |
|---|---|
| Alternative Names | APBA2 Antibody: X11L MINT2 LIN-10 HsT16821 X11-BETA D15S1518E MGC:14091 X11L Amyloid beta A4 precursor protein-binding family A member 2 Adapter protein X11beta Mint-2 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunofluorescence of APBA2 in human brain tissue with APBA2 antibody at 20 μg/mL.
Application
Western blot analysis of APBA2 in human brain tissue lysate with APBA2 antibody at (A) 1 and (B) 2 μg/mL.
Application
Immunohistochemistry of APBA2 in human brain tissue with APBA2 antibody at 10 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | APBA2 antibody can be used for detection of APBA2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | APBA2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | APBA2 Antibody is supplied in PBS containing 0.02% sodium azide. |
