Application
Western blot analysis in mouse heart tissue lysates (35ug/lane).| Product Name | APC Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25 |
| Product description | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.1) Chung, K.H., et al.Neurosurg Pediatr 6(4):372-376(2010) |
| Immunogen | This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Mouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | APC |
|---|---|
| Alternative Names | Adenomatous polyposis coli protein Protein APC Deleted in polyposis 25 APC DP25 |
| Molecular Weight(MW) | 312 kDa |
Application
Western blot analysis in mouse heart tissue lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
