Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Product description
This gene encodes a member of the basic helix-loop-helix
(BHLH) family of transcription factors. The protein activates
transcription by binding to the E box (5'-CANNTG-3'). Dimerization
with other BHLH proteins is required for efficient DNA binding.
This protein plays a role in the neuronal commitment and
differentiation and in the generation of olfactory and autonomic
neurons. Mutations in this gene may contribute to the congenital
central hypoventilation syndrome (CCHS) phenotype in rare cases.1) Phi, J.H., et al.Neurosurg Pediatr 5(6):608-614(2010)
Immunogen
This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.