This gene encodes a protein that contains a domain with
homology to the ancient conserved region of the archain 1 gene and
a domain that may be involved in binding ubiquitin-conjugating
enzymes. The protein encoded by this gene has been shown to bind to
the conserved membrane-proximal sequence of the cytoplasmic tail of
integrin alpha(IIb) subunits. These subunits play a crucial role in
the integrin alpha(IIb)beta(3) inside-out signalling in platelets
and megakaryocytes that leads to platelet aggregation and thrombus
formation. This gene overlaps the gene for mitochondrial serine
protease 25.1) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Immunogen
This AUP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the C-terminal region of human AUP1.
Western blot analysis in Hela cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.