The protein encoded by this gene acts as receptor for
arginine vasopressin. This receptor belongs to the subfamily of
G-protein coupled receptors which includes AVPR1A, V2R and OXT
receptors. Its activity is mediated by G proteins which stimulate a
phosphatidylinositol-calcium second messenger system. The receptor
is primarily located in the anterior pituitary, where it stimulates
ACTH release. It is expressed at high levels in ACTH-secreting
pituitary adenomas as well as in bronchial carcinoids responsible
for the ectopic ACTH syndrome. A spliced antisense transcript of
this gene has been reported but its function is not known.1) van West, D., et al. Psychiatry Res 179(1):64-68(2010)
Immunogen
This AVPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the C-terminal region of human AVPR1B.
Western Blot at 1:1000 dilution Lane 1: HUVEC whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.