Application
Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).| Product Name | BCL XL Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.1) Basu A, et. al. ( 2003) Mar 13; 538 (1-3): 41-7Cheng E. H. -Y. et. al. (1996) Nature 379:554-556. Sattler M. et. al. (1997) , Science 275:983-986. Muchmore S. W. et. al (1996) . Nature 381:335-341Yu J., Zhang L. Mol. (2001) Cell 7:673-682 |
| Immunogen | BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL . |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BCL2L1 |
|---|---|
| Alternative Names | BCLX BCL2L BCLXL BCLXS Bcl-X bcl-xL bcl-xS PPP1R52 BCL-XL/S P53 Apoptosis regulator Bcl-X |
| Molecular Weight(MW) | 30 kDa |
| Tissue Specificity | This antibody detects endogenous level of total BCL-XL protein. |
| Entrez Gene | 598 |
|---|---|
| Protein Accession | NP_612815.1 |
Application
Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).| Application Notes | Western Blot: 1:500~1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
