Application
Western blot analysis of BCL6 in rat lung tissue lysate with Bcl6 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide| Product Name | BCL6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | BCL6 Antibody: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).1) Ye BH, Chaganti S, Chang CC, et al. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J. 1995; 14:6209-17. |
| Immunogen | BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6. The immunogen is located within amino acids 370 - 420 of BCL6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| BCL6 antibody can be used for detection of BCL6 by Western blot at 1 μg/mL. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BCL6 |
|---|---|
| Alternative Names | BCL6 Antibody: BCL5 LAZ3 BCL6A ZNF51 ZBTB27 BCL5 B-cell lymphoma 6 protein B-cell lymphoma 5 protein BCL-6 |
| Molecular Weight(MW) | 78 kDa |
| Tissue Specificity | Three alternatively spliced transcript variants have been observed |
| Entrez Gene | 604 |
|---|---|
| Protein Accession | NP_001124317 |
Application
Western blot analysis of BCL6 in rat lung tissue lysate with Bcl6 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide| Positive Control | 1) Cat. No. 1462 - Rat Lung Tissue Lysate |
|---|---|
| Application Notes | BCL6 antibody can be used for detection of BCL6 by Western blot at 1 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | BCL6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | BCL6 Antibody is supplied in PBS containing 0.02% sodium azide. |
