This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)1) Kimura W, et al. (2007) Hepatogastroenterology. 54 (80): 2203-8. Naeem M, et al. (2002) Hum Pathol. 33 (12): 1182-7. Jankulovski N, et al. (2006) Prilozi. 27 (2): 59-70.
Immunogen
c-Kit (Ab-721) antibody was raised against a peptide sequence around aa.719~723 (N-E-Y-M-D) derived from Human c-Kit.