Application
Western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the detected the C2 protein (arrow).| Product Name | C2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.1) Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010) |
| Immunogen | This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000 | |
| Species Reactivity | HamsterHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | C2 |
|---|---|
| Alternative Names | Complement C2 C3/C5 convertase Complement C2b fragment Complement C2a fragment C2 |
| Molecular Weight(MW) | 83 kDa |
Application
Western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the detected the C2 protein (arrow).| Application Notes | For WB starting dilution is: 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
